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Biomedical Sciences and Translational Medicine - Main themes and areas

RESEARCH FIELDS

Curriculum Neuroscience
In vitro and in vivo models of neurodegenerative diseases
Molecular mechanisms of neurodegeneration and neuroprotection
Alzheimer’s disease: molecular and cellular mechanisms
Identification of biomarkers for Alzheimer’s disease
Parkinson’s disease: molecular and cellular mechanisms
Identification of biomarkers for Parkinson’s disease
Physiopathology and therapy of schizophrenia, depression and bipolar disorder
Receptors and transduction signalling
Receptor-receptor molecular and functional interactions
Production of induced pluripotent stem cells (iPS) from human fibroblasts
Differentiation of iPS into neuronal phenotypes: a new model to study human diseases
Mitochondriogenesis and neuronal bioenergetics
Experimental models of brain ischemia
Neuroimaging in the diagnosis of central nervous system diseases
Identification of genotype/phenotype profiles in the fronto-temporal disease
Neurochemistry and genetics of behaviour
Identification of risk factors for brain ischemia in young patients
Role of tumor stem cells in brain tumor development and growth
Histopathological characterization of brain alterations in mouse models of non-tumor disorders of the CNS

Curriculum Immunology and Oncology
Identification and characterization of new angiogenetic factors
Identification of new peptidomimetic compounds with antineoplastic activity
Signalling of angiogenetic growth factors
Interactions of tumor and stromal cells with the extracellular matrix
Role of the FGF/FGFR system in tumor growth and vascularization
Development of new models to investigate tumor growth, invasion and metastasis formation in zebrafish
Anti-tumor chemotherapy and heart damage
Characterization of new chemotactic factors and receptors
Mechanisms regulating pro- and anti-inflammatory cytokines  
Role of dendritic cells in inflammation
Cellular and molecular mechanisms of cancer immunosurveillance
Innate mucosal immune system
Antibodies-mediated tissue damage
Modulation of immune responses in patients with rheumatic diseases
Role of the JAK/STAT pathway in neoplastic transformation
Molecular mechanisms of neoplastic transformation in mucosal sino-nasal melanoma
Angiogenesis and brain tumors
Role of thymus in primary immunodeficiency in humans and mouse models

Curriculum Pharmacology and Microbiology
Conventional and non-conventional therapy of heart failure
Prognostic factors of chronic heart failure
Early diagnosis of heart failure in patients treated with antineoplastic drugs
Biomarkers for cardiotoxicity in patients treated with antineoplastic drugs
Identification of biomarkers to predict the sensitivity to pharmacological therapy in oncology
Identification and validation of new targets for the therapy of Parkinson’s disease
Identification and validation of new targets for the therapy of L-DOPA-induced dyskinesia in Parkinson’s disease
Identification and validation of new targets for the development of new drugs for Alzheimer’s disease
Receptor heterodimerization and transduction signalling
Experimental therapy of neuroendocrine diseases
Experimental therapy of bone diseases
Experimental therapy of ocular diseases
Mechanisms of microorganism-host interaction
Biological activity of microbial antigens
Development of vaccines and immunomodulators: characterization in vitro and in vivo
Immune escape mechanisms activated by microorganisms
Molecular epidemiology of pathogens
Brain tumors: experimental models and translational approaches

TEACHING AND RESEARCH ACTIVITY
The teaching and research training period is three years and is organized in credits (CFU). Students should obtain at least 60 CFU/year.

RESEARCH TRAINING ACTIVITIES
Research activity is specific for each curriculum and includes:
Research on a specific project under the supervision of a tutor
Participation in seminars and lectures given in the subject area. Seminars are organized by the Department of Molecular and Translational Medicine and by other Departments whose reserachers and professors belongs to the Teacher Committee and are given by experts in the field

Journal Clubs
Students  actively participate in Journal Clubs organized by the Research Group.

Progress reports on research activity
Students are required to periodically report on their research activty to their research group. At the end of each year students are required to present the results of their research activity to the Teacher Committee.

Participation in technical workshops or courses
Oral or poster presentations at national and international meetings
Students should be the lead authors of the paper presented

Research Stages in Qualified Reserach Centers in Italy or other Countries
Students should spend a period in a qualified Research Center in Italy or abroad. The maximum allowed stay abroad is 18 months

Publication of papers in high-impact scientific journals

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