Portale di Ateneo - En.Unibs.it

Mechanisms regulating drug absorption
Concepts of plasma peak and therapeutic window
Mechanisms regulating drug distribution
Binding of drugs to plasma proteins
Biotransformation of drugs and its clinical relevance
Mechanisms of drug elimination
Concepts of volume of distribution, clearance and half-life of drugs and their clinical relevance
Molecular targets of drugs
Receptor classification and transduction signalling
Drug-receptor interaction
Drug classification: agonists, partial agonists, inverse agonists and antagonists
Dose-response curves, concepts of drug efficacy and potency
Mechanisms of receptor desensitization and supersensitivity; Concept of drug tolerance
Therapeutic index and its pharmacological significance
Variability in the response to drugs
Interactions among drugs