Portale di Ateneo - En.Unibs.it

Introduction to Pharmacology. Drug discovery and development. Pharmacovigilance. Elements of pharmacoeconomics. Therapeutic effects, collateral and toxic effects. Placebo effect.

Pharmacokinetics: absorption, distribution, metabolism, excretion; concepts of bioavailability, clearance, half-life and steady state plasma concentration.

Pharmacodynamics: sites of action of drugs; receptors and signal transduction mechanisms; dose-effect relationship; concepts of potency and efficacy of drugs, agonism and antagonism, desensitization and hypersensitivity; therapeutic index.

Variability factors in response to drugs. Drug interactions: pharmacokinetic and pharmacodynamic aspects. Drug-food and drug-herb interactions.

Principles of antineoplastic chemotherapy; theoretical bases of polychemotherapy and anticancer drugs of more frequent use. Principles of antibacterial and antiviral chemotherapy and categories of drugs most frequently used. Prevention of antibiotic resistance.